Natrilix SR

Indapamide

Essential HTN in adults.

1 tab daily.

May be taken with or without food: Preferably taken in the morning. Swallow whole w/ water, do not chew.

Hypersensitivity to indapamide or other sulfonamides. Hypokalaemia. Hepatic encephalopathy; severe hepatic impairment or renal failure.

History of sulfonamide or penicillin allergy. Discontinue use if photosensitivity reactions; hepatic encephalopathy which can progress to hepatic coma; choroidal effusion w/ visual field defect, transient myopia, acute angle-closure glaucoma occur. Hyperuricaemic patients; hypovolaemia. Avoid exposure to sun or artificial UVA. Monitor water & electrolyte (plasma Na, K, Ca, Mg) balance, blood glucose regularly. +ve reaction in doping tests. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Preexisting renal insufficiency. Avoid use during pregnancy. Not recommended during lactation. Childn & adolescents.

Hypokalaemia; hypersensitivity reactions, maculopapular rashes.

Increased plasma lithium. Increased risk of ventricular arrhythmias w/ Torsade de pointes-inducing drugs eg, class IA & III antiarrhythmics, some antipsychotics (eg, phenothiazines, benzamides, butyrophenones, pimozide), bepridil, cisapride, diphemanil, erythromycin IV, halofantrine, mizolastine, pentamidine, sparfloxacin, moxifloxacin, vincamine IV, methadone, astemizole, terfenadine. Reduced antihypertensive effect w/ systemic NSAIDs eg, COX-2 selective inhibitors, high-dose ASA (≥3 g daily). Risk of sudden hypotension &/or acute renal failure w/ ACE inhibitors. Increased risk of hypokalaemia w/ IV amphotericin B, systemic gluco- & mineralocorticoids, tetracosactide, stimulant laxatives. Increased antihypertensive effect w/ baclofen. Hypokalaemia &/or hypomagnesaemia predisposed to digitalis toxicity w/ digitalis prep. Increased incidence of hypersensitivity reactions to allopurinol. Hypo- or hyperkalaemia w/ K-sparing diuretics eg, amiloride, spirinolactone, triamterene. Increased risk of metformin-induced lactic acidosis. Increased risk of acute renal failure w/ iodinated contrast media (large doses). Increased antihypertensive effect & risk of orthostatic hypotension w/ imipramine-like antidepressants, neuroleptics. Decreased urinary Ca elimination. Increased plasma creatinine w/ ciclosporin, tacrolimus. Decreased antihypertensive effect w/ corticosteroids, systemic tetracosactide.

Diuretics

C03BA11 - indapamide ; Belongs to the class of low-ceiling sulfonamide diuretics.

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